Cortisol pathway: How cortisol is related to HGH and Role of L glutamine and L tyrosine

7). Cortisol pathway


The majority of my investigation and focus these days is centered on the whole endocrine system. Currently I am much more enthusiastic about taking a look at how the human endocrine system functions as a whole to be able to see the bigger picture.

The hypothalamus is commonly disregarded in referring to those hormones and the function it plays. The pituitary gland which releases HGH into the body is dictated by the hypothalamus.


The “hypothalamic-adenohypophyseal AXIS” regulates the discharge of GHRH into the anterior pituitary which energizes the discharge of HGH. It also handles the release of somatostatin or GHIH into the anterior pituitary to slow down the production and release of HGH.

An axis is essentially a feed back loop. It manages the balance of various hormones present in the loop system.

Up till now, we have understood how neurotransmitters like Dopamine and hormones like Ghrelin and Somatostatin are a major factor in HGH production.

Ghrelin is a gut hormone that controls appetite, stimulates the release of GHRH, increases HGH and counters the effects of somatostatin.

The combination of a dopaminergic pathway, insulin pathway, cholinergic (somatostatin suppression) and igf-1 pathway create a powerful environment in the axis that stimulates a HGH pulse.

However, if your body has higher levels of cortisol, then that means it “prioritizes” cortisol over dopamine.

More cortisol implies less HGH and more HGH implies less cortisol.

So, if you lower cortisol, it gives out a signal to the body to start using more of dopamine, producing more dopamine and producing more HGH.

Cortisol will usually be taken care of if you have focused on the “warming and cooling NTs” pathway as well. However, if your current work-life balance is out of whack, you don’t enjoy deep restful sleep or you are chronically stressed, chances are you have a high cortisol.


The interesting thing is Cortisol supports Dopamine function when you’re under stress, for the reason that during those demanding or nerve racking times you burn off enormous amounts of dopamine.

Having said that, when you’re stressed for “too much time” or even days on end, complications arise from the prolonged high cortisol levels.

Your brain becomes accustomed to utilizing cortisol for energy, it will become an inner hormonal strategy for life in your body.

You’re hooked on the cortisol rush and also have the false impression that you’re in charge of your surroundings and keeping yourself on top of stress.

Chronically stressed people want control, may have the illusion that they are in control and find a kind of satisfaction in it.

However, Excessive cortisol results in fat gain especially around the stomach.

Cortisol & Belly Fat

If you’re fat and still have high energy, likelihood is your body is burning up cortisol constantly to aid your low dopamine levels.

So, how to deal with Cortisol and increase HGH :-

i). Understand the “warming and cooling NTs” pathway and the importance of deep sleep.

ii). Use the amino acids tyrosine by eating more high protein foods and wheat germ. An HGH supplement containing L tyrosine will help.

iii). Another very powerful supplement that will help in cortisol lowering is L-glutamine.

iv). Eliminate meals that reduce dopamine

  • Sugar and other forms such as high fructose corn syrup, corn syrup, fructose, dextrose, agave, sucralose, molasses, and syrup. Use Stevia as your main sweetener.
  • HFCStruths1
  • High glycemic carbohydrates: cake, crackers, white bread, white rice, pasta, pies, potatoes, and processed foods.

v). Take care of depression or chronic stress if any

Try meditation and mindful relaxation strategies.


vi). Control Depression if any

Depression and HGH do not go together. If you wish to improve your HGH levels, you will have to get this in check: depression contributes to lower HGH levels and is highly related to erectile dysfunction as well, which needless to say will only result in more depression.

Additionally, a lot of us don’t understand that long term depression generally contributes to diabetes, heart disease and loss of human brain tissue on top of that.

Recommended HGH products

I recommend these two HGH products – Genf20 Plus and HyperGH 14X.

Insulin pathway: How HGH and Insulin are related and how Chromium and choline supplements can help?

6). Insulin and blood sugar pathway


Insulin is a powerful, direct inhibitor of HGH secretion from the pituitary gland.

Now we’ll talk about one of the most crucial, efficient and interesting pathways to produce more HGH naturally.

Unfortunately mishandling of or not understanding this mechanism is one of the reasons people fail to increase their hGH levels even if they use a HGH supplement.

Enough scientific evidence exists that low blood sugar, and thereby low insulin stimulates the hypothalamus to produce and release hormones that increase “human growth hormone” manufacture and discharge in the pituitary gland.


This is the body’s mechanism of ensuring survival, because HGH provides energy and prevents muscle loss to occur, so during times of “low calories or low energy”, HGH does the job.

And vice-versa too.

So, high insulin (caused due to high glucose levels in blood) means less HGH.

We talked about IGF-1 earlier. IGF-1 (Insulin-like Growth Factor 1) is basically exactly that; it’s a hormone that has comparable attributes to insulin and outcomes on the body (it even adheres to the exact same receptors) as insulin, however it is created under totally reverse conditions.

Whereas the hormone insulin is secreted by the pancreas as a result of elevated blood glucose levels, IGF-1 is produced by the liver in times of low blood sugar. We learnt earlier that the effects of HGH and IGF-1 are basically the same, in fact HGH gets converted to IGF-1 in the liver.

The interesting thing here is low blood glucose levels increase both HGH and IGF-1.

Increased blood levels of cortisol, glucose and even HGH itself reduce production and secretion of HGH by signaling the pituitary to stop producing any more HGH.

HGH is launched into your circulatory system at fairly regular intervals (between 3-5 hours) and the quantity produced and launched into your system from the pituitary gland is predominantly based mostly on the factors outlined above.

It’s safe to assume, having said that, that for many people, a large part of growth hormone secretion occurs while asleep.

However, a good HGH supplement will have ingredients that will make use of this “insulin” based pathway or mechanism.

Here are four crucial ways by which HGH enhancement can be done:-

1). Minimizing insulin or glucose levels during sleep

Strategize intelligently your last meal of the day very carefully.


You need to minimize the insulin while you sleep and this will have an effect on maximizing growth hormone during sleep.

Many ancient cultures and scriptures consistently focus on the advice that there should be a gap of at least 3 hours or so between your last meal and your sleep.

This makes sense from the HGH perspective, because while you’re sleeping, you’d be having minimal levels of insulin because blood glucose would begin transporting across the body and its levels will decrease.

Your last meal of the day is the most crucial for sustaining a powerful GH/IGF-1 axis. A high-protein, low-carbohydrate snack before going to bed assists HGH production via two ways.

First, it contributes greatly to minimize insulin release and makes it possible for maximum endogenous GH secretion.

Second, necessary essential and conditionally essential amino acids present in protein will help the endogenous HGH release.

2). Minimizing insulin and Maximizing the effectiveness of Glucose transfer in the body during daytime

Let’s talk about what breakfast you should be consuming while taking hGH supplements.

If you are a bodybuilder and work out in the morning, then eat breakfast according to your needs.

If you are NOT a bodybuilder and only interested in anti aging benefits, I recommend you consume low carbs, healthy fats and moderate amount of protein in breakfast.

Why I recommend this? Because by maintaining the carbs (and thus insulin) low, consuming a healthy dose of fat and a moderate amount of protein, you are going to turn on necessary protein synthesis, mobilize fat, encourage ketogenesis and again take full advantage of growth hormone release throughout the morning and afternoon.


You’ll actually be making use of your body fat as energy to sustain or develop muscle. No matter what glucose the human brain would need for whatever purpose, it’s going to have it because of endogenous production in the liver.

If you are taking a HGH supplement that contains L-glutamine, glutamine from it can be transformed into glucose to help you bring glucose levels back in balance. So, overall your outside “carbs” requirement will decrease, thereby controlling your insulin.

Glutamine plays a crucial function in the control of blood glucose, or blood sugar. When amounts of glucose are low, for example in hypoglycemia, your system transforms glutamine in the liver and kidneys into glucose to help you bring glucose levels back in balance.

It’s now extensively recorded that under suitable conditions, glutamine is important for cell proliferation, that it can act as a respiratory system fuel and that it can enhance the function of stimulated immune cells.

Therefore, in essence, you’ll be making use of your body fat as energy. This strategy will also promote weight loss while being on HGH supplements.

Another way you can enhance HGH production is by enhancing effectiveness of glucose transfer in consuming supplements that help to control blood glucose levels during day like Chromium.


The University of Maryland Medical Center describes that even though a chromium deficiency is rare, up to 90 percent of men and women in the United States have persistently ‘abnormal’ amounts of chromium, particularly individuals who participate in physically demanding exercise, older people, women that are pregnant and those that take in large amounts of sugar.

Interestingly chromium supplements are also taken by a lot of dieters around the world for weight loss mainly because it helps regulate glucose levels and energy.

Chromium functions by assisting the hormone insulin in its functions of controlling blood glucose levels. If you don’t have enough insulin or if your body is resistant against it’s effects, you can consume a good amount of food but still will not be able to utilize it as energy.

This is actually the mechanics powering “diabetes”, which is known by medical experts as an inability to produce or use insulin.

Selective focus on the word "diabetes". Many more word photos in my portfolio...
Selective focus on the word “diabetes”. Many more word photos in my portfolio…

According to the Linus Pauling Institute, people who have a chromium deficiency generally have reduced glucose metabolism and a heightened insulin need.

So, their body is making too much “insulin” and this is triggering their pituitary gland to produce less “HGH”.

With adequate chromium supplementation, their capability to use insulin increases.

So, chromium will help you minimize insulin levels during the day and better glucose transport in the body and also provide energy.

Audrey H. Ensminger describes in “The Food and Nutrition Encyclopedia” that the GTF form of chromium is the type that delivers the most beneficial use and overall performance in your body, in comparison with other kinds of chromium. She contributes her research on it that carbohydrate diets cause exhaustion of GTF chromium.

Links to Chromium studies

So, L-Glutamine and Chromium are MUST have ingredients in a HGH supplement.

3). Learning to tolerate hunger, occasional fasting and causing “Ghrelin” to do its work

Learning to tolerate hunger is a tip that I’ll give to people interested in anti aging and not bodybuilding. However, if you are using an hGH supplement for bodybuilding, you can use intermittent fasting at times to give a good rejuvenating kickstart to your pituitary to secrete more HGH.

Let’s understand Ghrelin and how it’s connected to HGH and hunger.

Ghrelin hormone is a brain-gut peptide bodily hormone with two primary physical actions: growth hormone secretagogue action and food consumption inducer (causing hunger,in other words).

Ghrelin is made in the stomach and sets off a signal to the brain to encourage consuming food intake.

Ghrelin is a lot more than a simple growth hormone secretagogue. Ghrelin has other pursuits which includes stimulation of other pituitary hormones secretion, modulation of food intake and management of energy metabolism, monitoring gastric and pancreatic and even cardiovascular functions.

It’s also connected with sleep functions of the body and immune system. It decreases after you have eaten a meal.

So, basically Ghrelin directly causes hunger and HGH release at the same time. It causes HGH release by binding itself onto GHSR (a region of the brain) which in turn triggers the pituitary to release more HGH.

To state that human hunger is a complex phenomenon is a vast understatement. The detailed explanation of it would demand a number of articles or even an entire book.

Medical studies constantly unearths several interacting and overlapping hormones (such as leptin, ghrelin, peptide YY, GLP-1 and others)

All these hormones send signals to the brain based on a variety of factors like blood glucose levels, or when someone is eating something and cumulatively , their combined effect produces a sensation called hunger.

However, for our purpose, we can enhance HGH in the body by helping ourselves “manipulate” the hunger mechanism.

You see when you are hungry and don’t eat food immediately, the ghrelin continues to send signals to the brain to constantly produce more HGH. This is again, a survival mechanism.


If we fast for one day, the ghrelin response is so profound that HGH increases dramatically by 200-300%.

If we eat but do not satiate ourselves fully, the ghrelin response is not eliminated completely and HGH enhancement continues to occur.

If we eat a fully satiating food or more, the ghrelin response is nullified, it no more triggers the brain to produce more HGH.

So, the ideal scenario will be when we don’t eat to full satisfaction, probably half of what is required and somehow “blunt” the hunger. This will not nullify the “ghrelin” response.

So, what blunts hunger?

While dietitians argue over whether carbohydrates or fats are more satiating to “hunger” short-term, the evidence is in fact abundantly crystal clear: protein beats both of them out.

Increasing volumes of studies have revealed that both acutely and in the long-term, greater protein intakes assist in blunting hunger.

Another way you can blunt hunger is by feeling energetic and improving glucose transport in the body. Again, these supplements will help in this regard-

  • L Glutamine
  • Chromium
  • Acetylcholine (Alpha GPC or Phosphatidylcholine) which has some mild appetite suppressing activity and also increase energy

Other facts and tips you need to know

i). One 2008 medical investigation that examined the result of fasting during the Muslim observance of Ramadan discovered it had a positive impact on body mass and other health and fitness markers in trained athletes.

Fasting works so well for weight loss because it brings about the secretion of human growth hormone (HGH), which is also a fat-burning hormone. It also plays a huge role in muscle mass building.

Going on a fast also boosts catecholamines, which will increase resting energy expenditure, reduce levels of insulin, and makes the stored fat burn as energy resource. Collectively, these and other factors will help you becoming an efficient fat-burning machine.

ii). Studies have also demonstrated that high quality protein from meat and whey has a good influence on blood sugar, muscle building, altering body composition, and sparing muscle while dropping fat.

Steer clear of grain carbs, however. “Carb loading” is a blunder, specifically for men and women engaged in intense strength training, as you will burn up carb fuel in a short time and then “hit the wall.”

It also holds true for many people who begin their day with muffins, bagels, or pancakes as an example.

This kind of breakfast usually ignites a vicious cycle of “hunger” and snacking on even more carbs.

And the more carb snacks you eat , the more insulin resistant you in turn become. Your body requires more insulin and thereby you produce less HGH.

iii). Try to normalize your insulin sensitivity, which is key for optimal health and wellness as insulin resistance (which is what you get whenever your insulin sensitivity plummets) is a major instrumental factor to almost all chronic disease, from diabetes to cardiovascular disease and even cancer malignancy.

iv). Eat More Lean Protein(low-fat fish, skinless chicken, even low-fat red meat),

v). Eat More Fiber

vi). Test out food alternatives – especially try to find carbs substitutes – to determine what makes you feel satisfied. As an example, a lot of people say that oat meal gets them really full, even while a boxed cereal like wheat flakes actually leaves them starving.

vii). Try to normalize ghrelin levels, also known as “the hunger hormone”

viii). Lower triglyceride levels

ix). Reduce inflammation and focus on lessening of free radical damage

x). Eat (At-Least) Moderate Amounts of Dietary Fat

xi). Exercise

A variation of IGF-1 called mechano-growth factor (MGF) is made in reaction to extreme exercise, like weight lifting or sprinting. MGF acts mainly upon skeletal muscle tissues to bind satellite nuclei into the muscle tissues (sarcomere).

xii). Try Portion control and glycemic-load control

xiii). Steer clear of high-glycemic-load carbohydrates. In order to avoid the harmful spikes in “insulin” levels that minimize endogenous HGH levels and raise your risk for type 2 diabetes, keep away from highly processed carbohydrates like refined white bread and sugary cereal.

Also try to avoid high-glycemic-load foods such as white rice, potato chips, cookies, soda, and commercially processed fruit juices (high in fructose and lacking fiber).

As an alternative, focus more on nutrient and fiber-rich whole fruits, vegetables, nuts, and legumes (beans).

The majority of individuals who go on “low-carbohydrate” diets make a complaint of low energy and give up simply because they consume inadequate calories.

A half-cup of rice is 300 calories, while a half-cup of spinach is 15 calories!

Vegetables are not calorically dense, so it is crucial that you include legumes in your HGH diet.

xiv). Drink lots and lots of water and try to drink unsweetened tea or coffee.

Finally remember, Cognitive psychologist Judith Beck gave some of the best advice on the phenomenon of hunger.

Girl examining empty bowl at table
Girl examining empty bowl at table

She said: “hunger is not an emergency.”

If you are looking for recommended products, I recommend these two HGH products – Genf20 Plus and HyperGH 14X.

IGF-1 pathway: How to increase HGH by using Deer antler velvet to influence HGH-IGF-1 pathway

5). IGF-1 pathway


Endogenous (produced inside the body) HGH puts its actions into effect by “molecularly” joining straight to particular receptors on specific muscle tissues which includes muscles, connective tissue (tendons, ligaments, bone, and fat), as well as just about every major organ.


Growth hormone furthermore operates in a roundabout way by encouraging liver cells to produce and discharge polypeptide molecules referred to as somatomedins, of which, the most effective and extensively researched for its numerous health, anti aging and bodybuilding benefits is insulin-like growth factor-1 (IGF-1).

Like GH, IGF-1 has receptors through the entire body and assists in several capabilities.

The good news is, researchers are finding that the advantages of more youthful GH levels can also be made use of safely by naturally enhancing the body’s own hormone levels with the right nutrients and lifestyle practices.

One of those interesting natural ingredient , found in nature is Deer antler velvet” which is a natural combination of several amino acids and also contains IGF-1.

IGF-1 is primarily accountable for long bone growth in kids and it also has an effect on muscle mass growth and restoration of adults endocrine system.

In fact, IGF-1 is currently one of the most sought after natural compounds in the bodybuilding and athletic arena because of its immense benefits on muscle building, muscle recovery and preventing muscle loss or muscle degeneration (that comes naturally with aging).


IGF-1 significantly increases muscle mass by causing a condition of muscle hyperplasia (enhancement of quantity of freshly made new muscle cells) .

That’s why bodybuilders prefer it in a mass building steroid cycle when they need rapid increased muscle cell growth.

Some experts believe IGF supplementation is even better than HGH supplementation.

Why is that? It is because HGH causes IGF levels to rise in the liver first, then the muscle. While IGF-1 is more direct.

Getting the body’s energetic potential up, as well as using its ability to encourage the growth of satellite muscle cells and enabling them to mature into new muscle tissues it even supports the uptake and functions of many other ingredients in a HGH supplement.

More interestingly, it can result in the improved recovery of testicle size, if they have shrunk due to steroid abuse or other reasons like natural aging.

For bodybuilders, it prevents muscle loss and restores testicles size in PCT (post steroid cycle therapy).

H. Lee Sweeney, Ph.D., Professor and Chairman of Physiology at the University of Pennsylvaniais a well-known specialist on IGF-1 and the topic of the genetic enhancement of skeletal muscle in general.

lab rats

According to his statements on the muscle development, growth and rejuvenating attributes of IGF-1

Rats that were given IGF-1 and did nothing were bigger and stronger than rats that weren’t given IGF-1 but exercised.

And I’ll bet you guessed that rats that were given IGF-1 and exercised were the biggest, strongest rats in the house. The positive effects of IGF-1 on the rats continued for months after the rats stopped getting the supplemental hormone, whereas the exercising rats immediately lost size and strength as soon as they stopped exercising.

In a further research IGF-1 also seemed to prevent deterioration of muscle fibers in aged rats thereby confirming that it has a huge role to play in anti aging as well. Muscle loss and fat increase is one of the usually inevitable signs of aging.

The aging rats did not lose those muscles that are accountable for power and speed – and had the same speed and power output that they had when they were in their youthful years.

Scientific conclusions predict that when consumed by humans, it can increase “motor” ability of seniors (physical movement potential) like the capability to do more exercise.

Thus IGF-1 mechanism pathway , when combined with Dopaminergic and other pathways is one of the best strategy of anti aging, preventing muscle loss and to remain active during the later years and to naturally increase HGH in the body.

Deer antlers

When you consume deer antler velvet’s IGF-1 and also enhance HGH in the body by taking other ingredients, you are creating a perfect environment in the body to rejuvenate your “HGH-IGF-1” cycle or pathway.

Another compound having IGF-1 is Colostrum.

To quote Dr. Sweeney, “So we were able to conclude that IGF-1 could prevent all of the hallmarks of age-related atrophy and loss of skeletal muscle function in mammalian aging, at least based on the rodent model, and now we’re hoping to pursue this in larger animal models.”

For bodybuilders, a deer antler hGH supplement that includes this mechanism will help boost the potency of an anabolic cycle, this is as a consequence of a very unique quality of this supplement, that it will act on a number of different muscle tissues to reinforce growth.

Find out which body building product has Deer antler velvet and which anti aging product has it.

Such a HGH bodybuilding supplement will have the unique ability usually missed by other HGH products that is to encourage cell division, known as “mitogenesis”, and cell differentiation.

Which Means That In the case of IGF1 which does act on muscle tissue it will trigger the growth of fresh muscle fibers, and for bodybuilders consequently new receptors for testosterone.

Many bodybuilders have with one voice determined that IGF-1 enhances cycles of muscle building steroids considerably.

They also appear to be determined about its ability to decrease fat and enhance vascularity a good deal.

Another surprising effect for bodybuilders is that IGF-1 supplementation actually Reverses testicular atrophy.


Testicles if shrunken will come back to “full swing” as it were even in the middle of a steroid cycle.

There are a variety of lifestyle reasons that cause diminished GH and IGF-1 release. As an example, numerous reports say that central adiposity (the deposition of central body fat, around your belly region) causes huge GH decline.

Furthermore, it is well known that inadequate nutritional status, insufficient sleep, and not enough physical fitness can all bring about reduction in circulating GH and IGF-1, irrespective of age.

If you are looking for Deer antler velvet based HGH products, I recommend these two – Genf20 Plus and HyperGH 14X.

Cholinergic pathway: Suppressing somatostatin to increase HGH by using choline supplements – Phosphatidylcholine and Alpha GPC

4). Inhibition of somatostatin or Cholinergic pathway


Interesting studies propose that the growth hormone-blocker “somatostatin” can by itself be restricted with “choline” based supplements like Phosphatidylcholine or Alpha GPC or CDP-choline, thus delaying the rate at which growth hormone diminishes.

The hypothalamus manages serum GH levels with the release of two functionally opposing hormones: growth hormone-releasing hormone (GHRH) encourages GH release, while somatotropin release-inhibiting hormone decreases it.


The release of growth hormone is limited by somatostatin also referred to as SRIF, somatotropin release inhibiting factor, which occurs in two forms, one of 14 and the other of 28 amino acids, found in the hypothalamus and the digestive tract.

With the onset of aging, GH secretion from your anterior pituitary gland is reduced considerably with each passing year. Enough established data exists confirming the proposition that reduced GH release happens in part from increasing levels of “somatostatin” with aging.

The persuasive analysis indicated that administration of choline supplements to healthy elderly adults led to a spectacular four-fold improvement in serum GH levels, in contrast to baseline values.

Experts debated on why choline supplements increase hGH and one theory that came out and was later supported by more studies was that choline supplements increase “acetylcholine”, a neurotransmitter involved in cognitive functions and having wide spread functions across the body.

This neurotransmitter acts as “somatostatin” blocker or inhibitor and thus increases hGH. You can read more about acetylcholine on wikipedia, if you wish.

Understanding the limiting mechanism of somatostatin: A review from a pro bodybuilder who used GHRH steroids

Increasing hGH release in the body by employing GHRH (growth hormone releasing hormone) injections is quite popular among the bodybuilders who seek to enhance their levels of hGH to build muscle mass, gain incredible weight in short amounts and for competing in various bodybuilding events.

However, some pro bodybuilders have observed that even after application of some potent steroidal injections like GHRH, Ghrelin, or CJC-1295 , the hGH did not increase in the body dramatically or as good as they expected.

This again, is because of the increase in “somatostatin”, which increases as soon as hGH increases in the body, and prevents the pituitary form further releasing hGH, thereby evening out the GHRH injection effect.

This proves that even with hGH injections, you need a supplement that can stop or “block” somatostatin. Now, scientific studies and anecdotal experiences state that “acetlycholine” is that magical “somatostatin blocker”.

If you are looking for acetylcholine based HGH products, I recommend these two HGH products – Genf20 Plus and HyperGH 14X.

Below I present an interesting review from a pro bodybuilder.


When a secretagogue of GH, the kinds of as GHRH, Ghrelin, Hexarelin, or CJC-1295, alerts the GHSR (a region in the brain) it triggers the pituitary to produce HGH, IF, Somatostatin levels are reduced adequately making it possible for it. As soon as a rush of GH is launched, Somatostatin quantities will increase once again, therefore regardless of whether something is triggering the GHSR, it CANNOT alert the discharge of GH because of too high levels of Somatostatin .

Somatostatin is what regulates the negative feedback loop of pituitary GH release.

Right after a rush of GH is launched from a secretagogue irrespective of whether it was natural or artificially stimulated by using supplements or injections, Somatostatin concentrations will increase, blocking additional GH discharge right up to the point when HGH levels reduce, after which the ultra-short feedback systems of the hypothalamus-pituitary-axis (HPA) become active and result in Somatostatin levels to go down.

As soon as somatostatin concentrations reduce adequately, more HGH can be produced. Having said that under normal circumstances of using HGH supplements and injections, there will not be enough secretagogue compounds remaining in the body to result in more GH release once Somatostatin levels reduce.

For the reason that GHRH is also launched in surges, and only lasts 7 minutes upon its circulating release.

However if you are taking CJC-1295 injection (a long lasting hGH secretagogue steroidal injection), or taking an hGH supplement in pills form that you have taken for at least a week, so it has built in your system, these secretagogues will remain in your brain region, so as to continually giving signals to your pituitary gland to produce more hGH.

So what is the apparent limiters of GH release??

Well first, is the time period of GHRH or whatever secretagogue or supplement is signaling the release. It should be built in the system through continuous or regular intake so it’s able to ACT swiftly as soon as “Somatostatin” is reduced.

Whats the other limiter?

Somatostatin. Somatostatin is an inhibitor of GH discharge.

Surprisingly, very few bodybuilders or people interested in hGH supplements that I’ve seen has realized this.

That is, if an individual could slow down Somatostatin levels when using CJC-1295 injection or natural hGH supplements, you’d probably permit the secretagogue to alert a never-ending surge of GH (so long as the body was producing sufficient peptide, and that means you require a high protein diet considering that peptides are produced from amino acids in protein).

Experts might debate if it’s the most healthy or safest thing to increase hGH, but it is so far past the all-natural endocrine function it will contribute to good results nothing you’ve seen prior experienced or even thought possible with HGH of any sort or in whatever way previously accessible. I can attest to this as I’ve been tinkering with this recently.

Presently there is a class of substances called Acetylcholineesterase inhibitors, that inihibit the enzyme acetylcholineesterase, which is accountable for deactivating acetylcholine in the human brain.

Do you know what? Acetylcholine is an extremely effective chemical of Somatostatin.

Consequently Acetylcholineesterase inhibitors are roundabout somatostatin inihibitors, operating by growing acetylcholine levels which in turn hinder somatostatin levels.

There are 3 common acetylcholineesterase inhibitors (that increase acetylcholine in humans), they are;

  • Pyrostigmine (120mg/ed)
  • Galantamine (8-16mg/ed)
  • Huperzine A (50-150mcg/ed)

NOTE: Huperzine A dose is in the MICROgrams NOT MILLIgrams. If you take 50mg of Huperzine A you would DIE. I use Huperzine A myself for this.

The three of the aforementioned are acetylcholineesterase inhibiors and will thus have a similar inhibitory impact on somatostatin.

Begin with a low CJC-1295 dosage and a reduced acetylcholineesterase inhibitor dosage, and find out a good dose primarily dependent on your experiences.

Important considerations from this review

I’ve tried acetylcholineesterase inhibitors like Galantamine and unfortunately they come with some side effects like nausea or insomnia or lucid dreaming.

The next best strategy to increase acetylcholine is to use choline supplements like Alpha GPC or Phosphatidyl Choline which can be used for both anti aging and bodybuilding.

Interestingly, when ghrelin binds to GHSR receptors, it triggers the pituitary to produce HGH. Ghrelin is a hunger hormone that is released during the low blood sugar levels.

This signifies other mechanism by which hGH can be released, insulin pathway, that is maintenance of low glucose levels, and effective glucose transfer and transport throughout the body, and if possible tying fasting, or intermittent fasting.

Growth hormone secretagogue receptor, or ghrelin receptor, is a G protein-coupled receptor that binds ghrelin[1] and plays a role in energy homeostasis and regulation of body weight.

In the brain, they are located in the hypothalamic ventromedial nucleus and arcuate nucleus, as well as in ventral tegmental area dopamine neurons projecting to the nucleus accumbens.

I continue to do more exploring of this mechanism, I’m just publishing a few original suggestions. If a man or woman has an elevated level of somatostain, that comes naturally with aging, this strategy may really be helpful.

Usually pituitary functions like this;

1) Endogenous GH secretagogue or such as found in hGH supplements signals pituitary to release HGH, the quantity of GH produced is governed by somatostatin and secretagogue quantity.

2) Pituitary produces HGH creating a ‘surge’, right after, somatostatin concentrations increase therefore making the pituitary less competent or unresponsive to hGH secretagogues,

3) Once the HGH released happens to be consumed , Somatostatin concentrations will minimize once again, and once more secretagogues arrive, a further surge will happen and the process will be repeated.

So by taking a choline supplement (to get acetylcholine) like “Alpha GPC” or “Phosphatidyl Choline”, you can ABSURDLY modify the pituitary response of discharging more HGH by suppressing Somatostatin WHEN THE SECRETAGOGUE IS ALREADY INFLUENCING PITUITARY TO PRODUCE HGH.

Even after the hGH surge, somatostatin can not signal the pituitary to stop hGH release because it’s already blocked by acteylcholine.

This is a highly potent and powerful strategy to increase hGH and that is why I consider “Alpha GPC” and “Phosphatidyl Choline” a MUST have ingredient in any hGH supplement.

I recommend these two HGH products that contain both these ingredients – Genf20 Plus and HyperGH 14X.

Warming/cooling Neurotransmitters pathway: How it impacts HGH release and the role of deep sleep, GABA and L-glycine

3). Balancing “warming” and “cooling” neurotransmitters pathways



If you think maintaining a proper work-life balance is crucial, then you might be interested to know how it’s connected with hGH.

You see, humans were made to work during the day and take a deep, restful sleep at night. But, our lifestyle which is now full of chronic stress has caused a diminished balance of the “warming” (being active during day) and “cooling” (resting during night).

In their book Balance Your Brain, Balance Your Life, neurologist, Dr. Jay Lombard and preventative medicine specialist Dr. Christian Renna have given enough scientific proof that our health, energy and happiness are considerably impacted by our very own human brain equilibrium of “warming” and “cooling” neurotransmitters.

Dopamine, noradrenalin (norepinephrine), acetylcholine and glutamate are the major “warming” neurotransmitters (NTs), while serotonin and GABA are the chief “cooling” NTs.

Further these experts observe that “warming” NTs are dominating in the daytime, and the “cooling” alternatives predominate at night.

Studies now confirm that for optimum growth hormone release form the pituitary, the warming and cooling NTs in the body should be balanced.

That’s why when we were kids or teens, many of us lived life with a good balance, good equilibrium of warming/cooling and thereby produced more hGH.

However, with age and as we get into the more “stressful” years of “work”, this balance gets disturbed.

The experts also observed that Dopamine is our primary warming NT.

So, if you’re experiencing any of the following symptoms, there is a huge chance that you are having a possible warming NT/DA deficiency,


    • – weight gain (especially central body fat, around belly region)


    • – low energy


    • – apathy or feeling of helplessness


    • – difficulty focusing or concentrating while trying to understand or learn


    • – lack of motivation


    • – low testosterone in men


    • – depression


    • – forgetfulness


    • – reduced speed of information processing


    • – low potential of abstract thoughts


    • – decreased interest in things that people otherwise enjoy


Lombard and Renna provide a 150 question self-test questionnaire which can help people assess if they’re likely to be suffering from a warming or cooling NT deficiency.


They also claim that L-dopa supplement taken at breakfast may be a good option to restore neurological balance to the brain. And interestingly, L dopa enhances growth hormone in the body via same dopaminergic pathway, and one mechanism by which this supplement might be so effective in alleviating the above symptoms is the increase in “growth hormone” that comes with it.

A tyrosine supplement does the same job as L dopa, only better, because L dopa has some toxic side effects involved.

Considering that GH release happens mainly at night, making certain very good sleeping practices is absolutely necessary for men and women trying to enhance their natural levels of GH.

However, the fact is that one-third of adults report at least random rounds of insomnia, and about one-third of them are afflicted by sleeping disorders or disrupted sleep on a more persistent schedule, to the level that it consistently hinders day time performance.

For an incredible number of sleepless among us, there might be good news-in the kind of a relatively inexpensive, naturally sourced amino acid known as L-glycine.

Inside the central nervous system, glycine performs as an inhibitory neurotransmitter, actively taking part in a highly essential role of commencing normal patterns of REM sleep. This role of glycine is well documented in this regard.

A large part of GH secretion takes place at night during slow-wave (deep) sleep instead of REM sleep.


It is extensively recorded that insufficient sleep, abnormal sleeping habits, and low quality sleep can considerably hinder GH secretion.

In addition to high-intensity exercise, a crucial all-natural incitement of endogenous GH secretion is sleep.

To enhance sleep further, sustain good sleep hygiene routines: stick to a standard and regular time of going to bed and getting out of bed ; do not are drink alcoholic beverages or caffeine 4-6 hours before going to bed; and keep extra light and sound out of the bedroom.

The sleep hormone “melatonin” is also helpful in improving the pulsatile hGH release.

Interesting point about the pineal gland that releases the sleep hormone “melatonin” is that it is extremely prone to calcification as we grow older. That might be a reason behind the crisis of insomnia.

Another supplement that can help with deep sleep is GABA, another must have ingredient in any hGH supplement.


GABA or gamma-Aminobutyric acid, acts as an inhibitory or “relaxing” transmitter in the mature brain, inducing deep sleep and helping men and women balance the warming/cooling equilibrium.

If you are reading carefully at this point, you must have understood that the “Dopaminergic” and “warming/cooling equilibrium” balance is a powerful combination and regardless of age, it’s going to produce in a pulse of GH.

Balancing dopamine-serotonin (“motivation” and “satisfaction”) is optimal for both the release of melatonin and growth hormone. And melatonin further increases growth hormone.

While taking an hGH supplement, if your warming/cooling equilibrium is reached, you’ll observe:-


    • Energy is increasing, truly observe it in the afternoons


    • Facial skin appears better


    • Much deeper sleep, way deeper. Some people feel groggy for about 30 minutes after wakeup which is fine.


More tips:-

– Get to sleep in completely dark room. Furthermore, just protecting your eyes isn’t sufficient as the epidermis can sense light. Melatonin manufacturing takes place in total darkness.

– At wakeup take a look at sun for 2-3 minutes.

– If at all possible get up at dawn and take a look at sun as it looks on horizon, during those times you can look straight at the sun.

– Should you wake up when sun have risen, look two three fingertips below the sun or right at the sun but with shut down eyelids.

– Regardless of whether it is cloudy or not, still do your best at taking a look at the brightest sky.

Dopaminergic pathway: Relation between Dopamine and Growth Hormone, How L tyrosine and Alpha GPC can help?

2). Dopaminergic pathway

Another way the human body can be made to produce more hGH is by increasing the levels of a neurotransmitter called “dopamine” in the human brain.

Dopamine is a crucial brain chemical associated with motor performance (physical movements) and general motivation, arousal, excitement. One reason why the aging adults find it hard to move their body, like finding it difficult to get out of chair or bed, having low energy to walk or run, etc. is that they have low levels of dopamine.

This natural chemical is also taking part in other areas like it enables you to learn new skills or gain new insight and it governs the encoding of stimulating elements present in the world into the brain.

Anything you enjoy in life, like food, sex, entertainment activities, video games, fun, or even popcorn is somewhat encoded in your brain via dopamine.

So, dopamine is basically an “encoded” signal of joy.


Practically all drugs of abuse, like heroin and other opiates, alcoholic beverages, benzoylmethylecgonine, cocaine, amphetamine and nicotine activate dopamine neuronal systems.

Dopamine is a giant powerful chemical and it is what provides you with the energy lift to get out of bed after you awake and continue with daily routine with motivation.

Additionally, it works a big part in the libido and sexual performance.

One of the main functions of dopamine produced by the hypothalamus is to slow down the secretion of prolactin from the anterior lobe of the pituitary gland, states the Massachusetts General Hospital Neuroendocrine Clinical Center.

Prolactin lowers testosterone levels in men and too much prolactin can cause a pituitary tumor.

Studies confirm that dopamine acts as a modulating (balancing) hormone in the brain and protects and enhances the pituitary function of the brain.

The biggest benefit of dopamine though is that it’s a powerful growth hormone booster.

Interestingly, it’s also connected to testosterone in men. Insufficient dopamine protection of the anterior pituitary gland can also result in hypogonadism in men, reducing their libido, minimizing their manufacturing of sperm and quite possibly leading to erectile dysfunction.

Obstruction of dopamine to the pituitary may also result in a condition called gynecomastia or breast enlargement in men.

To increase growth hormone via Dopaminergic pathway, you need

– More calcium

The exact mechanism how dopamine enhances hGH is still being researched, however experts believe that it does so by increasing another hormone called GHRH which acts by increasing intracellular calcium concentration in pituitary cells which secrete growth hormone.

The release of GHRH is elevated during the slow sleep. It is triggered by hypoglycemia, arginine, dopamine, serotonin, alpha-2-mimetics like clonidine which was employed for treating short stature.

The keywords for us here are :- arginine, dopamine, serotonin.

We’ll talk about serotonin in warming/cooling equilibrium pathway.

– Increase in Dopamine levels

One of the best supplements to increase dopamine naturally is L-tyrosine. This supplement is being used as a nootropic as well, and its users have consistently reported dramatic energy, increased motivation and vigor.


Tyrosine, is not an essential amino acid because it can be produced from the amino acid phenylalanine. It is transformed into dopamine and norepinephrine.

The use of tyrosine supplements leads to alertness and mental arousal. Tyrosine works in a smooth, consistent, efficient way, to improve alertness and focus, along with mood, enhances dopamine in the body and thereby increases hGH.

Another supplement that is incredibly powerful in enhancing dopamine, mental focus, alertness and physical energy is Alpha GPC.

Some really interesting research has been done on its applications in anti aging and bodybuilding.

– Deep sleep at night

deep sleep

Dopamine encourages the pituitary gland to produce and secrete growth hormone. The release of growth hormone is activated by GHRH, growth hormone releasing hormone, also referred to as somatocrinin, secreted by the hypothalamus in a pulsatile mode and in line with a circadian cycle that reaches its peak throughout the slow sleep.

To ensure you get a really deep sleep and dopamine actually works to increase your HGH levels, you’ve got to understand the warming/cooling equilibrium pathway.

Amino acids pathway: What is the catch in using amino acids to enhance HGH?

1. Amino acids pathway

If you ingest or consume too much or more than usual of something, your body knows how to use it. Excess fat intake can cause cholesterol in sedentary individuals.

When bodybuilders doing strenuous exercises take fat, it gets converted to cholesterol and a good portion of that cholesterol gets converted to testosterone, which they require for working out in the gym. All in all, the human body does a pretty good job of assessing what reason or purpose the compounds are to be used for.

AS we know, hGH is a peptide hormone comprising of several amino acids. So, when we consume lots of amino acids, we are giving the body a signal to produce more of hGH. Amino acids like L-Arginine, L-Ornithine, L-Lysine, L-Tyrosine, L-Glutamine, L-Glycine, L-Valine all give this signal to the body.

That is the reason why intravenous injections of amino acids were documented to increase human growth hormone dramatically.

Experts believe that amino acids intake signals the body to produce more GHRH (growth hormone releasing hormone) which in turn signals the pituitary to produce more hGH.

However, every action has an equal and opposite reaction. This is what the homeostasis system of the body is supposed to do, it tries to maintain the same hormonal levels in the body.



So, when you take in all those amino acids, the body will try its best to counter the effects so that the change in hGH levels does not happen. That is the reason why after few days of those amino acids injections, the growth hormone levels in the subjects returned to normal levels.

Scientists are still researching on the exact mechanisms of the “homeostasis” which tries to keep the same levels of the hormones in the body, however here are some well established mechanisms:-

i. After a surge in growth hormone levels, the human body produces “somatostatin”, a hormone that signals the pituitary gland to stop producing more growth hormone.

ii. When the human body takes excess amino acids, somatostatin also signals the “intestines” to stop absorption of amino acids. However, “somatostatin” action can be blocked by using other ingredients that work via cholinergic pathway.

So, you see everything has a catch. That’s why you need a multi-ingredient HGH supplement that works on different pathways to bring about a comprehensive effect.